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Abstract Details

Activity Number: 661
Type: Contributed
Date/Time: Thursday, August 2, 2012 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #306733
Title: A Multiplicity Adjustment Problem in Clinical Trials with Multiple Co-Primary Endpoints
Author(s): Yi Ma*+
Companies: Quintiles, Inc.
Address: 121 Costero Aisle, Irvine, CA, 92614, United States
Keywords: multiplicity ; type I error ; co-primary endpoints

Consider a clinical trial contain 3 equally important primary endpoints, the treatment is claimed effective compared to placebo if 2 or more endpoints are significant. The problem is how to adjust the multiplicity efficiently in order to strong control the overall type I error. We propose a simple solution to the problem along with a proof. A generalization to n (n>3) co-primary endpoints will also be discussed.

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