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Activity Number: 526
Type: Contributed
Date/Time: Wednesday, August 1, 2012 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #306681
Title: Homozygosity by Descent and Risk for Schizophrenia in Palau
Author(s): Cong Lu*+ and Nadine Melhem and Bernie Devlin
Companies: Carnegie Mellon University and University of Pittsburgh and University of Pittsburgh
Address: Baker Hall 132 Department of Statistics, Pittsburgh, PA, 15213, United States
Keywords: Homozygosity by Descent ; Schizophrenia ; Permutation test

We examine whether Homozygosity by Descent (HBD) is associated with schizophrenia and related psychotic disorders in the Palauan population. A sample of 197 cases and 158 controls, for a total of 355 subjects, and 261,854 high quality SNPs were analyzed. We use Beagle algorithm to call HBD regions. We compared cases and controls on the distribution of HBD regions, the length of HBD regions, and HBD sharing. Monte Carlo permutation tests were conducted. Simulations were also conducted to find genomic regions where HBD sharing is significantly higher than expected by chance. Although cases and controls were similar with respect to the occurrence of HBD, cases were more likely to have longer HBD regions. We also found cases to show HBD sharing in genomic regions that have been previously implicated in schizophrenia in populations of European ancestry.

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