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Abstract Details

Activity Number: 515
Type: Contributed
Date/Time: Wednesday, August 1, 2012 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #306667
Title: Analyzing Time-to-Event of Interest: Methods of Competing Risk Analysis
Author(s): Kathy Zhang*+
Companies: Amgen, Inc.
Address: 1120 Veterans Blvd., South San Francisco, CA, 94080, United States
Keywords: cancer trials ; time to event ; competing risk

In Cancer clinical trials, we are often interested in analyzing time to first event of interest (e.g. special adverse events) given subjects may die or experience other events that preclude the onset of the event of interest, or alter the probability of the onset of the event. The traditional KM estimates of event of interest may be biased in this setting. In this paper, we compared several conventional competing risk analysis approaches (cumulative incidence method, cause specific hazard method) based on a simulation study. A real life example was also given at the end.

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