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Abstract Details

Activity Number: 275
Type: Topic Contributed
Date/Time: Tuesday, July 31, 2012 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #306638
Title: Confounding of Post-Study Treatment in Survival Analysis
Author(s): Yanping Wang*+ and Min Zhang
Companies: and University of Michigan
Address: 14281 Chariots Whisper Drive, Carmel, IN, 46074, United States
Keywords: causal inference ; survival analysis ; cancer clinical trials

In clinical trials of advanced cancers, overall survival (OS) remains the gold standard for demonstrating clinical benefit of a new treatment. One challenge of using OS as an endpoint is the potential confounding of post-study treatment (PST) on the study treatment effect. Statistical methods have been proposed to adjust for PST and estimate the causal effect of study treatment. In this talk, we will illustrate the potential confounding of PST and discuss different methods for adjusting for the confounding. We will evaluate and compare the methods through simulations and real applications.

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