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Abstract Details
Activity Number:
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275
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, July 31, 2012 : 8:30 AM to 10:20 AM
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Sponsor:
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Biometrics Section
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Abstract - #306638 |
Title:
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Confounding of Post-Study Treatment in Survival Analysis
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Author(s):
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Yanping Wang*+ and Min Zhang
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Companies:
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and University of Michigan
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Address:
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14281 Chariots Whisper Drive, Carmel, IN, 46074, United States
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Keywords:
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causal inference ;
survival analysis ;
cancer clinical trials
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Abstract:
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In clinical trials of advanced cancers, overall survival (OS) remains the gold standard for demonstrating clinical benefit of a new treatment. One challenge of using OS as an endpoint is the potential confounding of post-study treatment (PST) on the study treatment effect. Statistical methods have been proposed to adjust for PST and estimate the causal effect of study treatment. In this talk, we will illustrate the potential confounding of PST and discuss different methods for adjusting for the confounding. We will evaluate and compare the methods through simulations and real applications.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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