JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 23
Type: Topic Contributed
Date/Time: Sunday, July 29, 2012 : 2:00 PM to 3:50 PM
Sponsor: Section on Government Statistics
Abstract - #306583
Title: Development of Analysis Pipeline for a Genome-Wide Association Study of Schizophrenia and Bipolar Disorders: An Integrated SNP, Gene, and Pathway Analysis
Author(s): Clarence K. Zhang*+ and Hongyu Zhao and John Concato and J. Michael Gaziano and Philip Harvey and Larry Siever and Timothy O'Leary
Companies: VA Clinical Epidemiology Research Center, VA Connecticut Healthcare System and Yale School of Public Health and VA Clinical Epidemiology Research Center, VA Connecticut Healthcare System and Massachusetts Area Veterans Research and Information Center, VA Boston Healthcare System and Miami Veteran Affairs Healthcare System and University of Miami and Bronx VA Medical Center and Mt Sinai School of Medicine and VA Office of Research and Development
Address: 950 Campbell Ave., West Haven, CT, 06516, United States
Keywords: Schizohprenia ; Bipolar disorder ; GWAS ; pathway ; association

Schizophrenia and bipolar disorder are mental illnesses with substantial genetic components, and are prevalent diagnoses in the Veterans Health Administration (VHA). Genome wide association studies (GWAS) can identify genetic variants in multiple complex diseases. In this talk, we will introduce a GWAS study funded by the VA Cooperative Studies Program. Using a case-control design, we will compare the genomic variation of 9,000 Veterans with schizophrenia and 9,000 Veterans with bipolar disorder to the genomic variation of approximately 20,000 Veterans without these conditions. Given that the project is currently enrolling, our focus will be on development of the analysis pipeline that includes: data retrieval, genotype calling, quality control metrics, population stratification analysis, imputation, single marker association analysis, gene-based analysis, pathway based analysis, functional annotation, and other related studies. We will present data on enrollment and various quality measurements from an initial analysis. This project has the potential to advance the personalized treatment for two common mental disorders affecting veterans. 

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program

2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.