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Abstract Details

Activity Number: 126
Type: Contributed
Date/Time: Monday, July 30, 2012 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistical Computing
Abstract - #306551
Title: Using Simulated Annealing for RNA 3D Structural Comparisons
Author(s): Ryan Rahrig*+
Companies: Ohio Northern University
Address: Department of Mathematics and Statistics, Ada, OH, 45810, United States
Keywords: RNA ; simulated annealing ; alignment
Abstract:

In the study of RNA, an important task is finding the structural similarities and differences of two molecules. As the number of 3D structures available has been increasing dramatically in the past decade, it has become important and necessary for automated methods of RNA structural comparison to be developed. Some RNA molecules, such as ribosomal RNA, consists of hundreds or even thousands of nucleotides, making such a task computationally difficult. A method of RNA 3D alignment using a simulated annealing based approach has been developed and is presented. Comparisons of resulting alignments with those produced by other programs are included.


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