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Abstract Details

Activity Number: 342
Type: Contributed
Date/Time: Tuesday, July 31, 2012 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #306331
Title: Continual Reassessment Method: A Unified Approach
Author(s): Keying Ye*+ and Xiaobin Yang and Ying Ji
Companies: The University of Texas at San Antonio and Analytic Focus, LLC and The University of Texas at San Antonio
Address: Department of Management Science and Statistics, San Antonio, TX, 78249,
Keywords: continual reassessment method (CRM) ; Markov chain Monte Carlo ; phase I clinical trial

A new definition of the overall Maximum Tolerated Dose (MTD) is proposed and a unified model for discrete and continuous responses is developed. Probit models with latent variables are employed in the discrete model analysis. Theoretical properties of the model are investigated and some of simulation comparisons between the new model and some existing models are given.

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