The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Online Program Home
Abstract Details
|
Activity Number:
|
161
|
|
Type:
|
Topic Contributed
|
|
Date/Time:
|
Monday, July 30, 2012 : 10:30 AM to 12:20 PM
|
|
Sponsor:
|
Biopharmaceutical Section
|
| Abstract - #306309 |
|
Title:
|
An Adaptive Alpha Spending Approach in Group Sequential Trials
|
|
Author(s):
|
David Li*+
|
|
Companies:
|
Pfizer Inc.
|
|
Address:
|
500 Arcola Road, Collegeville, PA, 19426, United States
|
|
Keywords:
|
Alpha spending ;
group sequential trials
|
|
Abstract:
|
Alpha spending functions have become a very popular approach in clinical trials where several interim analyses are planned. This presentation will introduce an adaptive alpha spending approach when the interim analysis timings are pre-determined. The advantage of the proposed approach is that one can adjust the alpha to be spent at the next interim analysis based on the observed results at the current interim analysis: one can spend more next time if observed results are promising, or less otherwise, or even can skip the next interim analysis by spending zero to wait longer for the intervention takes effect.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2012 program
|
2012 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.