JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 253
Type: Contributed
Date/Time: Monday, July 30, 2012 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #306298
Title: Testing the Equality of the Efficiencies of Two Correlated Outcome Measures in Clinical Trials
Author(s): Youngju Pak*+ and John Hewett and Marian Minor and Nilotpal Sanyal
Companies: University of Missouri-Columbia and University of Missouri-Columbia and University of Missouri-Columbia and University of Missouri-Columbia
Address: 182 D Galina Hall, Columbia, MO, 65212, United States
Keywords: Clinical trials ; Efficiencies ; Clinical t Bootstrap-t confidence intervals ; Correlations ; Pain scales

In many of clinical trials, there will be more than one outcome variables. Anderson and Chernoff defined the efficiency to identify the variable which is the more sensitive in measuring change. We have developed the two tests for testing the equality of the efficiencies of two correlated variables and applied our methods to data from a arthritis clinical trial to compare efficiencies of 3 different Womac scales. An approximate Z-test and the bootstrap-t method are suggested to test the equality of efficiencies of two different outcome variables. When both sample size and correlation between two efficiencies are large, an approximate Z-test shows fairly good power. Application to data from an arthritis clinical trial show that the Womac difficulty scale is sensitive than both Womac pain.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program

2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.