JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 615
Type: Contributed
Date/Time: Thursday, August 2, 2012 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #306296
Title: Why Bother Psychometrics? One Example from the Hamilton Rating Scale for Depression (HRSD) in a Depression Trial
Author(s): Chengwu Yang*+ and Wenle Zhao
Companies: Penn State College of Medicine and Medical University of South Carolina
Address: 600 Centerview Dr., Mail Code A210, Hershey, PA, 17033, United States
Keywords: psychometrics ; factor analysis ; clinical trials ; depression ; instruments ; measurements

The Hamilton Rating Scale for Depression (HRSD) is widely used in depression trials as the primary measure of depression despite of its well-known severe psychometrical issues. In a trail that compared continuation electroconvulsive therapy vs. pharmacotherapy for depression relapse prevention, the total score of the HRSD items was used to define relapse, and no positive result was found. But this can be misleading, because the uni-dimensional assumption for the HRSD was wrong. In this study, the original data from that trial were used to investigate psychometrical issues in the HRSD. Confirmatory factor analyses (CFA) were implemented at 4 visits to test the uni-dimensional assumption, and it failed at all visits. Thus the total HRSD score cannot be used as the defining variable for relapse, results based on it was misleading, and may conceal some true positive findings. Exploratory factor analysis (EFA) on all of the HRSD items failed to yield a consistent factor structure across the 4 visits. Item-level analyses found statistically significant differences on 3 important items between the two arms. Psychometrics can play a key role in studies using instruments such as the HRSD.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program

2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.