JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 411
Type: Contributed
Date/Time: Tuesday, July 31, 2012 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #306230
Title: Vaccine Effectiveness Case-Control Studies: Out of Control?
Author(s): Elizabeth Zell*+ and Jennifer Verani and Michelle Groome and David Moore and Cynthia Whitney and Shabir A Madhi
Companies: CDC and CDC and Respiratory and Meningeal Pathogens Research Unit and Respiratory and Meningeal Pathogens Research Unit and CDC and National Institute for Communicable Diseases
Address: 3166 Bolero Dr, Atlanta, GA, 30341-5759, United States
Keywords: Vaccine Effectiveness ; Case-control study ; pneumonia ; Hospital Controls ; Community Controls

Case-control studies are commonly used to evaluate vaccine effectiveness (VE) following licensure. As many developing countries introduce newer, more costly vaccines, evaluation of the impact of these vaccines is important to justify their continued use. The use of hospital controls (HC) has become a common approach for these evaluations; rather than the more difficult community controls (CC). In an evaluation of pneumococcal conjugate VE against presumed bacterial pneumonia, we compared and contrasted VE estimates generated using HC and CC among HIV-uninfected children. Cases and HC were enrolled at Chris Hani-Baragwanath Hospital, Soweto, South Africa. CC were identified through birth registers at the same hospital. All controls were matched on case date of birth. Vaccinations received =14 days before case onset dates were considered valid doses. Dose- and age-based crude VE estimates for hospital controls ranged from 3-50% and for community controls from 23-65%. Although not statistically different, point estimates were higher using CC. Here we compare and contrast findings from these two groups to make recommendations for future VE studies using the case-control methodology.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program

2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.