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Abstract Details

Activity Number: 405
Type: Contributed
Date/Time: Tuesday, July 31, 2012 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #306107
Title: Minimal Plus One Design Points for Some Mixture Models
Author(s): Yanyan Li*+ and Damaraju Raghavarao
Companies: Teva Branded Pharmaceutical Products R&D, Inc. and Temple University
Address: 425 Privet Road, Horsham, PA, 19044, United States
Keywords: D-optimal Minimal Design ; Lack of Fit ; Second-degree mixture model
Abstract:

D-optimal minimal designs have been obtained for different mixture models with minimal support design points, i.e., the number of design points is equal to the number of parameters in the model. To test Lack of Fit, we need to add at least one additional distinct design point. Those distinct design points are within the design space with all factor levels greater than zero for practical reasons. We will discuss second-degree mixture model and second-degree mixture model with main effects and two factor interactions including one common factor. The new design will be compared with other possible designs for testing Lack of Fit.


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