The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Online Program Home
Abstract Details
Activity Number:
|
245
|
Type:
|
Contributed
|
Date/Time:
|
Monday, July 30, 2012 : 2:00 PM to 3:50 PM
|
Sponsor:
|
Biopharmaceutical Section
|
Abstract - #306068 |
Title:
|
Inferiority Index and the Behrens-Fisher Problem for Noninferiority Trials
|
Author(s):
|
George Y.H. Chi*+
|
Companies:
|
Janssen Pharmaceuticals R&D
|
Address:
|
12436 Over Ridge Rd, Potomac, MD, 20854, United States
|
Keywords:
|
Inferiority index ;
Non-inferiority trials ;
Heterogeneity of variances ;
Margin function ;
Behrens-Fisher problem ;
Welch's approximate t-test
|
Abstract:
|
The classical Behrens-Fisher problem poses the question regarding the form of the distribution of the test statistics under normality for the relative difference measure assuming heterogeneity of variances under the null hypothesis of a superiority trial. The so-called Behrens-Fisher distribution for the test statistic defined as the observed mean difference divided by the square root of the sum of the sample variances has been derived [Kim and Cohen (1998)]. Welch (1938) proposed an approximate t-test and derived its distribution. Dannenberg et al (1994) derived the corresponding extended Behrens-Fisher distribution for the test statistic under heterogeneity of variances for the equivalence hypothesis with a pre-specified equivalence margin for bioequivalence trials. In this paper, we will show how to apply the theory of inferiority index to derive an extended Behrens-Fisher distrib
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2012 program
|
2012 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.