JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 74
Type: Contributed
Date/Time: Sunday, July 29, 2012 : 4:00 PM to 5:50 PM
Sponsor: Biometrics Section
Abstract - #306018
Title: Practical Study Design Methods for Interval-Censored Failure Time Data
Author(s): Daniel Tancredi*+ and Danielle J Harvey and Laurel Beckett
Companies: University of California at Davis School of Medicine and University of California at Davis and University of California at Davis
Address: 2600 Kline Ct, Davis, CA, 95618, United States
Keywords: interval censoring ; panel data ; accelerated failure time ; Fisher information ; power and sample size calculations ; missing information principle

In many longitudinal studies with multiple inspection times the timing of a failure event of interest is impossible or impractical to observe exactly but one can observe the inspection times between which the event occurred. Examples of interval censored failure times include the onset of Alzheimer's disease in multiwave panel studies, the failure time of a hidden component in an industrial reliability study and the timing of HIV transmission in clinical trials. Key study design decisions include the number and timing of inspections and the sample size required to achieve suitably precise estimates of location parameters (e.g. means and regression coefficients) for failure time models. We propose practical methods for making these decisions, including graphical methods for understanding and minimizing information loss due to interval censoring and power and sample size calculation methods for interval-censored accelerated failure time regression models.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program

2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.