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Activity Number: 510
Type: Contributed
Date/Time: Wednesday, August 1, 2012 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #305943
Title: Optimization of Sampling Schemes for Population Pharmacokinetic/Pharmacodynamic Studies
Author(s): Sergei Leonov*+
Companies: Vertex Pharmaceuticals
Address: 130 Waverly Street, Cambridge, MA, 02139,
Keywords: optimal design ; Fisher information matrix ; pharmacokinetic models ; compartmental models ; D-optimality

We discuss the application of optimal model-based experimental design for finding the most informative sampling times in population pharmacokinetic/pharmacodynamic (PK/PD) studies which are described by nonlinear mixed effects models. We outline key components of the methodology, describe the PkStaMp software which constructs D-optimal designs for compartmental PK and combined PK/PD models, and provide examples of how the software was used for several studies

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