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Abstract Details
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Activity Number:
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510
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Type:
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Contributed
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Date/Time:
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Wednesday, August 1, 2012 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #305943 |
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Title:
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Optimization of Sampling Schemes for Population Pharmacokinetic/Pharmacodynamic Studies
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Author(s):
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Sergei Leonov*+
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Companies:
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Vertex Pharmaceuticals
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Address:
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130 Waverly Street, Cambridge, MA, 02139,
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Keywords:
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optimal design ;
Fisher information matrix ;
pharmacokinetic models ;
compartmental models ;
D-optimality
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Abstract:
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We discuss the application of optimal model-based experimental design for finding the most informative sampling times in population pharmacokinetic/pharmacodynamic (PK/PD) studies which are described by nonlinear mixed effects models. We outline key components of the methodology, describe the PkStaMp software which constructs D-optimal designs for compartmental PK and combined PK/PD models, and provide examples of how the software was used for several studies
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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