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Abstract Details

Activity Number: 358
Type: Roundtables
Date/Time: Tuesday, July 31, 2012 : 12:30 PM to 1:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #305911
Title: Overview of Subgroup Approaches Designed for Personalized Care
Author(s): Ann Lazar*+ and Wai-ki Yip and Marco Bonetti and Bernard F Cole and Xin Victoria Wang and Richard D Gelber
Companies: University of California at San Francisco and Harvard School of Public Health and Bocconi University and University of Vermont and Harvard School of Public Health/Dana-Farber Cancer Institute and Harvard School of Public Health/Dana-Farber Cancer Institute
Address: 3333 California Street, San Francisco, CA, 94118, United States
Keywords: Competing Risks ; Biomarkers ; Kaplan-Meier ; Hazard Ratio ; Interaction
Abstract:

This session will focus on subgroup approaches designed to evaluate treatment-effect heterogeneity, which may ultimately translate to tailored therapies for improved patient care. We will discuss the most recent developments in subgroup methodology, including the use of baseline risk scores in Subpopulation Treatment Effect Pattern Plots (STEPP), Multivariable Fractional Polynomial Interaction Approach (MFPI) as well as two-stage approaches.


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