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Abstract Details

Activity Number: 510
Type: Contributed
Date/Time: Wednesday, August 1, 2012 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #305902
Title: Estimating Heritability Based on Censored Twin Data
Author(s): Klaus Kähler Holst*+
Companies: University of Copenhagen
Address: Tavlekaersvej 23, Hvidovre, International, 2650, Denmark
Keywords: liability model ; right censoring ; random effects ; heritability ; inverse probability weighting

Classical methods for analyzing dichotomous traits in twin studies are based on threshold models (liability models) where random effects are used to separate enviromental and genetic factors. An important use of these models have been to examine the heritability of specific diseases. However, a major source of bias will in this situation occur due to right censoring at the the time of follow-up.

We will discuss alternative measures of associations and demonstrate how Inverse Probability Weighting techniques can be used to extend the threshold model to the situation where some observations are right censored. The proposed methods will be illustrated using simulations and using cancer data from danish twins.

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