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Abstract Details

Activity Number: 278
Type: Topic Contributed
Date/Time: Tuesday, July 31, 2012 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #305899
Title: Adaptive Methods Exploiting Connections Between Permutation Tests and Parametric Procedures
Author(s): Michael Proschan*+
Companies: National Institutes of Health
Address: 6700 A Rockledge Drive, Bethesda, MD, 20817, United States
Keywords: Permutation Tests ; Randomized Clinical Trial ; Basu's Theorem ; Adaptive Methods
Abstract:

Using blinded data to make adaptations in clinical trials and then applying a permutation test at the end is valid under certian circumstances. This talk is about the connection between permutation tests and t-tests, and it sheds light on whether certain t-tests are still approximately valid after making changes based on blinded data.


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