JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 615
Type: Contributed
Date/Time: Thursday, August 2, 2012 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #305811
Title: Exact Poly-K Test
Author(s): Matthew Jackson*+ and Mohammad Rahman and Karl K Lin and Ram C. Tiwari
Companies: FDA and FDA and FDA and FDA/CDER/OTS/OB
Address: , , ,
Keywords: Permutation test ; Poly-K test ; Exact test ; Carcinogenicity study

For animal carcinogenicity studies with multiple dose groups, positive trend (dose response relationship) test and pairwise comparisons of treated groups with control are generally performed using the Cochran-Armitage, Peto test, or Poly-K test. These tests are asymptotically normal test. Exact versions of the Cochran-Armitage and Peto tests are available based on the permutation test assuming fixed column and row totals. For the Poly-K test, column totals depend on the mortality pattern of the animals and can not be kept fixed over the permutations of the animals. Therefore, application of permutation test assuming fixed total does not give correct exact p-values. In this work a modification of the permutation test is suggested that can be applied to exact Poly-K test. This modification adjusts the column totals depending on the regrouping of animals in every permutation, and thus provides the correct exact p-values.

Disclaimer: This presentation reflects the views of the authors and should not be construed to represent FDA's views or policies

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program

2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.