JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 469
Type: Contributed
Date/Time: Wednesday, August 1, 2012 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #305693
Title: Addressing Interval Censoring in the Stepped Wedge Design of Cluster-Randomized Clinical Trials
Author(s): Tanya Granston*+ and James Hughes
Companies: and University of Washington
Address: 7422 Latona Ave. NE, Seattle, WA, 98115, United States
Keywords: mixed models ; interval censoring ; EM Algorithm ; trial design

The stepped wedge design of cluster-randomized trials has been growing in popularity and becomes increasingly relevant due to the need to efficiently evaluate the rollout of interventions that are individually efficacious in a community setting. The design is especially useful in resource limited settings where it is usually not feasible to introduce interventions all at once and where there are substantial clusters/communities/groups to provide answers regarding intervention effects. However, there remain limitations and outstanding issues to this design, which could potentially limit its usefulness where it's most needed. One such limitation is the lack of analytic methods to address interval censoring of time-to-event endpoints in the context of the stepped wedge design. We propose an EM Algorithm approach with cluster effect and true failure times as joint latent variables to address this issue in discrete time and evaluate the precision, consistency, and asymptotic normality of the hazard ratio estimator in simulations. Additionally, we outline the bias and power using this approach.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program

2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.