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Abstract Details

Activity Number: 253
Type: Contributed
Date/Time: Monday, July 30, 2012 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #305690
Title: How Are Mouse Models Correlated to Human Cancers?
Author(s): Lianbo Yu*+ and David Jarjoura
Companies: The Ohio State University and The Ohio State University
Address: 2012 Kenny Road, Columbus, OH, 43221, United States
Keywords: mulvariate modeling ; gene expression ; pathway analysis

Mouse models have been extensively used for mimicking human cancers. Often specific mice genotypes are developed that are consistent with the discovered mechanisms behind a human cancer. The consistency of mouse models and human cancers can be studied with gene expression arrays and other high dimensional methods. Differentially expressed genes found by the mouse model when compared to a wild type mouse should be associated with pathways similar to differentially expressed genes found when comparing cancer patients vs. healthy normals. We propose using multivariate contrasts across these four groups to find consistencies and inconsistencies across species in expression profiles. We compare this approach to other suggested previously.

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