How Are Mouse Models Correlated to Human Cancers?

• Activity Number: 253
• Type: Contributed
• Date/Time: Monday, July 30, 2012 : 2:00 PM to 3:50 PM
• Sponsor: Biometrics Section
• Author(s): Lianbo Yu*+ and David Jarjoura
• Companies: The Ohio State University and The Ohio State University
• Keywords: mulvariate modeling ; gene expression ; pathway analysis

Abstract

Mouse models have been extensively used for mimicking human cancers. Often specific mice genotypes are developed that are consistent with the discovered mechanisms behind a human cancer. The consistency of mouse models and human cancers can be studied with gene expression arrays and other high dimensional methods. Differentially expressed genes found by the mouse model when compared to a wild type mouse should be associated with pathways similar to differentially expressed genes found when comparing cancer patients vs. healthy normals. We propose using multivariate contrasts across these four groups to find consistencies and inconsistencies across species in expression profiles. We compare this approach to other suggested previously.