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Abstract Details
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Activity Number:
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427
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Type:
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Roundtables
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Date/Time:
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Wednesday, August 1, 2012 : 7:00 AM to 8:15 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #305646 |
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Title:
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Reducing Placebo Response in Adult and Pediatric Depression Studies
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Author(s):
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Qi Zhang*+
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Companies:
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Eli Lilly and Company
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Address:
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3924 Dolan Way, Westfield, IN, 46074, United States
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Keywords:
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Placebo Response ;
Depression ;
Pediatric ;
Adult
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Abstract:
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Depression trails have high failure rate due to high placebo response with even higher placebo response rate in pediatric studies compared with adult studies. In this discussion, we will share some literature regarding the design factors for placebo response in both Adult and Pediatric Depression studies. The common design considerations to reduce placebo response will be discussed which include the utilization of novel design (such as sequential parallel design), the number of sites, placebo randomization ratio, etc. We will also discuss the know predictors for placebo response. Then we will discuss the best design features to use, the difference between adult and pediatric studies regarding placebo response.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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