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Abstract Details
Activity Number:
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491
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 1, 2012 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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Abstract - #305616 |
Title:
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Related Causal Frameworks for Surrogate Outcomes in Randomized Trials, with Extensions to Observational Studies and Beyond
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Author(s):
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Marshall Joffe*+
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Companies:
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University of Pennsylvania
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Address:
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423 Guardian Dr, 602 Blockley Hall, Philadelphia, PA, 19104, United States
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Keywords:
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randomized trials ;
surrogate outcomes ;
causal inference
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Abstract:
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Most existing methods for surrogate outcomes in randomized trials fall into one of two paradigms: the causal effects paradigm and the causal association paradigm. The paradigms are complementary, with each dealing with some weaknesses in the other. These paradigms are readily extended to observational studies and time-varying treatments. Further, each one is relevant to characterizing the effects of partially manipulable variables.
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