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Activity Number: 134
Type: Contributed
Date/Time: Monday, July 30, 2012 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #305586
Title: Estimation and Comparison of Diagnostic Accuracy with Epidemiologically Clustered Case-Control Data
Author(s): Sungyoung Auh*+ and Jonghyeon Kim
Companies: National Institutes of Health and Otsuka Pharmaceutical
Address: 10 Center Dr, Bethesda, MD, 20892,
Keywords: Clustered Data ; Receiver Operating Characteristic curve ; Diagnostic test

Currently the estimation and inference of receiver operating characteristic (ROC) curve that quantifies the capacity of a diagnostic test, is restricted to the case where biomarker is obtained from two independent groups of subjects, cases versus controls. The ROC curve and the diagnostic measure derived from the ROC curve is biased when correlation is ignored in the clustered data or matched case and control data. We investigate parametric and non-parametric estimation of ROC curve to the case where a group of control subjects is matched to its case subject and present inference procedure.

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