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Abstract Details

Activity Number: 554
Type: Topic Contributed
Date/Time: Wednesday, August 1, 2012 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #305566
Title: Experimental Design for In Vitro Drug Combination Studies
Author(s): Gregory Hather*+ and Huaihou Chen and Ray Liu
Companies: Millennium: The Takeda Oncology Company and Columbia University and Millennium: The Takeda Oncology Company
Address: 35 Landsdowne Street, Cambridge, MA, , USA
Keywords: drug combinations ; experimental design ; cell viability ; synergy

In vitro drug combination studies typically involve a large number of wells with various concentrations of two drugs added together. To gain the most information from an experiment, what should the drug concentrations be? Here, we consider the case where the single drug response curves are known beforehand, but no previous data is available from the combination. We consider several designs, including C and D-optimal designs, and a factorial design. We evaluate these designs based on the expected variance of the synergy score for a large set of in vitro experiments performed at Millennium. Based on the results, we were able to identify which design was the most efficient and robust.

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