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Abstract Details

Activity Number: 231
Type: Topic Contributed
Date/Time: Monday, July 30, 2012 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #305431
Title: Bayesian Adaptive Phase II Trial with a Nonmonotonic Dose-Response Curve
Author(s): Yuyan Duan*+ and Robert Noble
Companies: and Aptiv Solutions
Address: 8 Hutchinson Rd., Winchester, MA, 01890, United States
Keywords: adaptive design ; bayesian rule ; phase II trial

A case study of a Phase II Bayesian adaptive design will be presented and issues will be discussed. Characteristics of this binary endpoint study include: (1) combination of proof of concept and dose-finding, and (2) potential for the dose-response curve to have a reflection point.

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