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Abstract Details

Activity Number: 515
Type: Contributed
Date/Time: Wednesday, August 1, 2012 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #305354
Title: Statistical Evaluation of Loewe Additivity Model and Bliss Independence Model
Author(s): Wei Zhao*+ and Lanju Zhang and Harry Yang
Companies: MedImmune and MedImmune and MedImmune
Address: 1 MedImmune Way, Gaithersburg, MD, 20878, United States
Keywords: Drug Combination ; Loewe Additivity ; Bliss Independence

Studies of drug combinations have become increasingly important, especially in treating malignant cancers. Researchers are interested in identifying compounds that act synergistically when combined. The synergistic effects are generally evaluated by Loewe additivity model or by Bliss independence model. Although several review papers have discussed the scenarios where these methods should be applied, however, none of the discussions was originated from a statistical point of view. It still remains unclear to statisticians which model is more appropriate to use for a given data set. In this presentation, we will use numerical simulations and real data sets to compare these two models. A general guideline on how to properly conduct drug combination analysis will be given.

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