JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 117
Type: Topic Contributed
Date/Time: Monday, July 30, 2012 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #305345
Title: Adjusting for Misclassification In Stratified Biomarker Clinical Trials
Author(s): Aiyi Liu*+
Companies: National Institute of Child Health and Human Development
Address: 7820 Lakeland Valley Dr, Springfield, VA, 22153-4105, United States
Keywords: Biomarkers ; Misclassi fication ; Personalized medicine ; Sensitivity and speci city
Abstract:

Clinical trials utilizing predictive biomarkers have become a research focus in personalized medicine. We investigate the e ffects of biomarker misclassification on the design and analysis of stratified biomarker clinical trials. For a variety of inference problems including marker-treatment interaction, we show that marker misclassifiction may have profound adverse eff ects on the coverage of con fidence intervals, power of the tests, and required sample sizes. For each inference problem we propose methods to adjust for the classification errors.


The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program




2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.