JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 412
Type: Contributed
Date/Time: Tuesday, July 31, 2012 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #305271
Title: Covariate Measurement Error Methods in Mediation Analysis with Failure Time Data
Author(s): Shanshan Zhao*+ and Ross Prentice
Companies: University of Washington and Fred Hutchinson Cancer Research Center
Address: 3716 NE 75th St., Seattle, WA, 98115, United States
Keywords: Measurement Error ; Failure Time ; Mediation Analysis ; Biomarker ; Women's Health

Biomarker data have been used to understand the biological pathways through which a treatment affects outcomes in randomized clinical trials. However, when biomarkers are measured with error, its mediation assessment may be distorted. Traditional correction methods do not extend easily to failure time outcomes. We propose calibration procedure based on induced hazard function to correct for bias caused by measurement error in the mediator. This method allows covariate distribution to vary over time and differ between treatment arms, and involves an approximation to the partial likelihood. This method is applicable to both technical measurement error and to error defined as variation from a long-term covariate mean. Simulation results show that the treatment effect biases of the 'naïve' approach are much reduced by this calibration. This method is illustrated through biomarker studies in the Women's Health Initiative postmenopausal hormone therapy trial.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program

2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.