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Abstract Details
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Activity Number:
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454
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 1, 2012 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #305241 |
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Title:
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Propensity Score M:N Matching Approach in Medical Device Trials in Subgroup Analysis
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Author(s):
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Hong Wang*+ and Songtao Jiang and H. Terry Liao
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Companies:
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Boston Scientific Corporation and Boston Scientific Corporation and Boston Scientific Corporation
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Address:
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100 Boston Scientific Way, Marlborough, MA, 01752, United States
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Keywords:
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propensity score m:n matching ;
drug-eluting stent ;
clinical outcomes ;
Subgroup
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Abstract:
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The propensity score matching method has been widely used in clinical trial analyses. The Greedy 1:1 matching algorithm has been recently applied to assess the clinical outcome with imbalanced baseline characteristics for two medical device treatments in a non-randomized trial design. We will use this approach to assess the dynamic m:n matching in diabetic patient subgroup to compare clinical outcomes in medical device trials. A case example data will be used to demonstrate the difference among 1:1 matching, m:n matching, and quintile approach.
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