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Abstract Details

Activity Number: 475
Type: Contributed
Date/Time: Wednesday, August 1, 2012 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistics in Epidemiology
Abstract - #305074
Title: Age, Incidence, Followup, Bias
Author(s): Lev S Sverdlov*+
Companies: Redmond Analytics
Address: 4631 148th Avenue NW, Bellevue, WA, 98007-7879, United States
Keywords: Age-related disorders ; Longitudinal studies ; Treatment ; Bias ; Incidence ; Followup

Possible bias in longitudinal studies of the intended and unintended effects of treatment on the incidence of age-related disorders (ARD) (cancer, CAD, CVD, Alzheimer, etc.) is analyzed. Randomized cohorts can be imbalanced by the mix of initial ages, follow up times and aging during the study. The probability of this imbalance and its evolution due to random and non-random dropout are explored. The cohorts can be exposed to different cumulative hazards through the nonlinear dependence of hazard on age. Naïve comparison of the incidence of ARD can lead to false positive or negative results. Adjustment in the Cox regression setting requires an explicit model of the complex age/follow up/outcome relationships. Methodological aspects and practical suggestions for controlling or mitigating the bias are discussed.

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