The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Online Program Home
Abstract Details
Activity Number:
|
475
|
Type:
|
Contributed
|
Date/Time:
|
Wednesday, August 1, 2012 : 8:30 AM to 10:20 AM
|
Sponsor:
|
Section on Statistics in Epidemiology
|
Abstract - #305074 |
Title:
|
Age, Incidence, Followup, Bias
|
Author(s):
|
Lev S Sverdlov*+
|
Companies:
|
Redmond Analytics
|
Address:
|
4631 148th Avenue NW, Bellevue, WA, 98007-7879, United States
|
Keywords:
|
Age-related disorders ;
Longitudinal studies ;
Treatment ;
Bias ;
Incidence ;
Followup
|
Abstract:
|
Possible bias in longitudinal studies of the intended and unintended effects of treatment on the incidence of age-related disorders (ARD) (cancer, CAD, CVD, Alzheimer, etc.) is analyzed. Randomized cohorts can be imbalanced by the mix of initial ages, follow up times and aging during the study. The probability of this imbalance and its evolution due to random and non-random dropout are explored. The cohorts can be exposed to different cumulative hazards through the nonlinear dependence of hazard on age. Naïve comparison of the incidence of ARD can lead to false positive or negative results. Adjustment in the Cox regression setting requires an explicit model of the complex age/follow up/outcome relationships. Methodological aspects and practical suggestions for controlling or mitigating the bias are discussed.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2012 program
|
2012 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.