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Abstract Details
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Activity Number:
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516
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Type:
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Contributed
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Date/Time:
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Wednesday, August 1, 2012 : 10:30 AM to 12:20 PM
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Sponsor:
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ENAR
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| Abstract - #305034 |
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Title:
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A Prognostic Signature of Defective P53-Dependent G1 Checkpoint Function in Melanoma Cell-Lines
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Author(s):
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Bernard Omolo*+ and William Kaufmann and Joseph Ibrahim and Craig Carson
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Companies:
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University of South Carolina Upstate and The University of North Carolina at Chapel Hill and The University of North Carolina at Chapel Hill and The University of North Carolina at Chapel Hill
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Address:
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800 University Way, Spartanburg, SC, 29303, United States
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Keywords:
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cancer ;
gene expression ;
G1 checkpoint ;
p53 ;
melanoma ;
signature
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Abstract:
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Successful therapy for metastatic cancer often depends upon p53-dependent apoptosis. So it is important to determine p53 function in primary lesions. While mutations in p53 are uncommon in melanoma, abnormalities in p53 function are common. We describe a method for estimating p53 signaling function in melanomas from a signature of gene expression. The signature was found to be prognostic for the development of distant metastases in melanoma patients. We conclude that expression profiling of primary melanomas should be clinically useful.
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