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Abstract Details

Activity Number: 279
Type: Topic Contributed
Date/Time: Tuesday, July 31, 2012 : 8:30 AM to 10:20 AM
Sponsor: IMS
Abstract - #305025
Title: Experimental Designs for Functional MRI with Compound Stimulus
Author(s): Ming-Hung Kao*+
Companies: Arizona State University
Address: 725 N. Dobson Rd., Chandler, AZ, 85224, United States
Keywords: Design efficiency ; Functional Magnetic Resonance Imaging ; Genetic Algorithm
Abstract:

Well planned experimental designs are crucial to the success of functional magnetic resonance imaging (fMRI) experiments. They help to collect informative fMRI time series to make valid and precise inference about brain activity in response to mental stimuli. However, obtaining good fMRI designs is arduous; it requires careful consideration regarding statistical and practical issues as well as major computational efforts. In this article, we obtain efficient fMRI designs. In contrast to existing studies, we consider compound stimuli, each consisting of two or more separate components. The use of such compound stimuli is not uncommon. For example, a mental task may follow a cue so that the experimental subject can be more prepared. Our design approach is also suited to studies where subjects are asked to respond (e.g., make a decision) to each stimulus. Designs that we obtain are compared with designs widely in use.


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