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Abstract Details

Activity Number: 346
Type: Contributed
Date/Time: Tuesday, July 31, 2012 : 10:30 AM to 12:20 PM
Sponsor: Section for Statistical Programmers and Analysts
Abstract - #304958
Title: Application of Mitigated Fraction in a Vaccine Study Using SAS
Author(s): Mathew Anthony Rosales*+
Address: 6220 Falabella Circle, Kalamazoo, MI, 49009, United States
Keywords: mitigated fraction ; SAS ; vaccine study ; nonclinical trials ; bootstrap ; confidence interval

Mitigated fraction is frequently used to evaluate the effect of an intervention in reducing the severity of a particular outcome, a common measure in vaccines study. It utilizes rank of the observations and measures the overlap of the two distributions using their stochastic ordering. Percent lung involvement is a common endpoint in vaccines study to assess efficacy, and mitigated fraction is used to estimate the relative increase in probability that a disease will be less severe to the vaccinated group. A SAS macro was develop to estimate the mitigated fraction and its confidence interval. The macro provides an asymptotic confidence interval and a bootstrap-based interval. For illustration, an actual vaccine study was used where the macro was utilized to generate the estimates.

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