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Abstract Details

Activity Number: 34
Type: Contributed
Date/Time: Sunday, July 29, 2012 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #304938
Title: Power and stability properties of resampling-based multiple testing procedures with applications to gene oncology studies
Author(s): Dongmei Li*+ and Gang Han
Companies: University of Hawaii at Manoa and Moffitt Cancer Center
Address: 2640 Dole Street, Honolulu, HI, 96822-2342, United States
Keywords: Resampling ; multiple testing procedures ; Power ; Stability

Resampling-based multiple testing procedures are widely used in genomic studies to identify differentially expressed genes and to conduct genome-wised association studies (GWAS). However, the power and stability properties of these popular resampling-based multiple testing procedures have not been extensively evaluated yet. Our study focus on investigating the power and stability of several resampling-based multiple testing procedures frequently used in microarray studies through simulations and gene oncology examples and provide some guidance and cautions for researchers using those methods in microarray data analysis.

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