Complex Interaction Effects and Model Selection Strategies

• Activity Number: 110
• Type: Topic Contributed
• Date/Time: Monday, July 30, 2012 : 8:30 AM to 10:20 AM
• Sponsor: Biometrics Section
• Author(s): Nicholas Schork*+ and Ondrej Libiger and Jill Waalen and Guia Guffanti and Wei Chen and Gerald Berenson and Sathanur Srinavasan
• Companies: The Scripps Research Institute and The Scripps Research Institute and The Scripps Research Institute and Columbia University and Tulane University and Tulane University and Tulane University
• Keywords: Epistasis ; Genetics ; Interactions ; Model Selection

Abstract

There are many interaction types to consider in genetic association studies, with gene x gene and gene x environment being the two broadest. In this presentation, we consider modeling situations in which the effect of a particular genetic variant on a phenotype is exacerbated by the influence of another phenotype or physiologic process. Assessing such models requires multivariate longitudinal data collected on a large cohort with appropriate genotype information. We consider the application of such models to the Bogalusa Heart Study data. We also consider the utility of model selection strategies for identifying different types of interaction effects.