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Abstract Details

Activity Number: 253
Type: Contributed
Date/Time: Monday, July 30, 2012 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #304914
Title: A Discriminant Function for Renal Inflammatory Activity Associated with Lupus Nephritis
Author(s): Alice Hinton*+ and Haikady Nagaraja and Brad Rovin
Companies: The Ohio State University and The Ohio State University and The Ohio State University
Address: 2415 Northglen Dr, Columbus, OH, 43224,
Keywords: Biomarkers ; Classification ; Repeated Measures Data ; Multivariate Normal Model ; Lupus Nephritis

A trivariate normal model with a patterned covariance matrix is proposed to examine the longitudinal patterns in a dataset which is composed of lupus nephritis patients who experience repeated renal inflammatory activity. The model accounts for the correlation between three variables of interest as well as the correlation which is present across time. Conditional distributions are utilized to develop a discriminant function which identifies patients who are currently experiencing inflammatory activity. The training dataset provides MLE's for each of the parameters present in the discriminant function. The discriminant function complete with MLE's can then be used for patient classification in future datasets.

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