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Abstract Details
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Activity Number:
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494
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 1, 2012 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #304900 |
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Title:
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Multi-Reader Diagnostic Imaging Case Studies: Components of Variance
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Author(s):
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Brandon Gallas*+
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Companies:
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FDA/CDRH/OSEL/DIAM
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Address:
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WO Bldg 62, RM 3124, Silver Spring, MD, 20993, United States
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Keywords:
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MRMC ;
AUC ;
variance ;
imaging ;
ROC
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Abstract:
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In this talk we will introduce the framework for analyzing multi-reader ROC diagnostic imaging case studies. This framework is the launching point for the advanced methods discussed in the other talks of this session. The core of the framework is the accounting for reader variability in addition to case variability in the analysis of diagnostic imaging performance metrics. There are several methods (and software) for representing and estimating the constituent components of variance, and we will summarize a few. The methods are often referred to as multi-reader multi-case (MRMC) variance analysis methods. We will demonstrate MRMC analysis of several real studies and discuss the sizing of future studies.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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