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Abstract Details
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Activity Number:
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319
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, July 31, 2012 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #304815 |
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Title:
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Statistical Issues in Over-Running or Under-Running Clinical Trials
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Author(s):
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Jing Xu and Bin Zhang*+
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Companies:
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Millennium Pharmaceuticals, Inc. and Millennium Pharmaceuticals, Inc.
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Address:
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35 Landsdowne Street, Cambridge, MA, 02139,
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Keywords:
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overrunning ;
underrunning ;
group sequential clinical trials ;
type I error
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Abstract:
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In group sequential clinical trial, sometime the trials continue even though the pre-specified boundary for stopping was crossed. In some other cased, trials had to be terminated or abandoned before stopping rules can be fulfilled for various reasons. We investigate the statistical properties of these situations under different scenarios, and investigate ways to preserve type I error in these situations.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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