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Abstract Details
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Activity Number:
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647
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Type:
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Topic Contributed
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Date/Time:
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Thursday, August 2, 2012 : 10:30 AM to 12:20 PM
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Sponsor:
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International Indian Statistical Association
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| Abstract - #304740 |
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Title:
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Estimation of a Proportion in a Mixed Sample Using Gene Expression Data
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Author(s):
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Bertrand Clarke*+ and Jennifer L. Clarke
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Companies:
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University of Miami and University of Miami
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Address:
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1120 NW 14th St, Miami, FL, 33136,
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Keywords:
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proportion ;
mixed sample ;
gene expression ;
high dimensional
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Abstract:
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We present a technique for estimating the proportion of cells in a mixed sample of cells for instance, a sample containing some cancerous cells and some normal cells using gene expression data. The idea is to find an optimal transformation of the data so that a modified ratio will be consistent for the proportion. This estimate can be used to identify the under- and over-expression of genes in cell types of interest. We verify the accuracy of our technique in several examples and present theory giving conditions under which the technique works more generally.
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