JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 647
Type: Topic Contributed
Date/Time: Thursday, August 2, 2012 : 10:30 AM to 12:20 PM
Sponsor: International Indian Statistical Association
Abstract - #304740
Title: Estimation of a Proportion in a Mixed Sample Using Gene Expression Data
Author(s): Bertrand Clarke*+ and Jennifer L. Clarke
Companies: University of Miami and University of Miami
Address: 1120 NW 14th St, Miami, FL, 33136,
Keywords: proportion ; mixed sample ; gene expression ; high dimensional

We present a technique for estimating the proportion of cells in a mixed sample of cells for instance, a sample containing some cancerous cells and some normal cells using gene expression data. The idea is to find an optimal transformation of the data so that a modified ratio will be consistent for the proportion. This estimate can be used to identify the under- and over-expression of genes in cell types of interest. We verify the accuracy of our technique in several examples and present theory giving conditions under which the technique works more generally.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program

2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.