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Abstract Details

Activity Number: 661
Type: Contributed
Date/Time: Thursday, August 2, 2012 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #304485
Title: Multiplicity Strategies for Multiple Treatments and Multiple Endpoints
Author(s): Kenneth Liu*+ and Duane Snavely and Nancy Liu and Jin Xu and Ivan Chan and Paulette Ceesay
Companies: Merck and Merck and Merck and Merck and Merck and Merck
Address: UG1C46, North Wales, PA, 19454-1099, United States

When testing multiple hypotheses, multiplicity adjustments are used to control the Type 1 error. Many clinical trials test multiple hypotheses which are organized into multiple treatments and multiple endpoints. We present a framework that provides multiplicity strategies for these types of problems. In particular, graphical solutions (Bretz et al, 2009) and shortcuts (Hommel et al, 2007) will be presented using examples.

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