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Abstract Details
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Activity Number:
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351
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Type:
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Contributed
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Date/Time:
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Tuesday, July 31, 2012 : 10:30 AM to 12:20 PM
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Sponsor:
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WNAR
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| Abstract - #304428 |
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Title:
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Imputing Missing Genotypes in Transmission Disequilibrium Test with One Sibling
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Author(s):
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Gulhan Bourget*+
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Companies:
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California State University Fullerton
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Address:
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800 N State College, Fullerton, CA, 92834, United States
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Keywords:
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Missing Genotypes ;
One Sibling ;
TDT ;
Type I Diabetes ;
rTDT
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Abstract:
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The Transmission Disequilibrium Test (TDT) compares frequencies of transmission of two alleles from heterozygote parents to an affected offspring. This test requires all genotypes to be known from parents and an offspring. However, obtaining all genotypes in a study might not be possible in some cases. The techniques imputing only missing parental genotypes or ignoring missing parental genotypes but considering unaffected and affected genotypes have been proposed. Sebastiani, Abad-Grau, Alpargu and Ramoni proposed robust TDT (rTDT) technique to impute missing genotypes in any family members. However, rTDT is a conservative test and lacks power. We propose a new method Mendelian Inheritance TDT (MITDT-ONE) that controls type I error well and has higher power than the rTDT. The MITDT-ONE uses Mendelian Inheritance property, and takes population frequency of disease allele and marker allele into account in the rTDT method.
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Authors who are presenting talks have a * after their name.
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