JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 318
Type: Topic Contributed
Date/Time: Tuesday, July 31, 2012 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #304361
Title: A Systematic Review of Models to Predict Recruitment to Multicenter Clinical Trials
Author(s): Andrew Cook*+
Companies: University of Southampton
Address: Alpha House, Southampton, SO16 7NS, United Kingdom
Keywords: recruitment ; model ; RCT ; systematic review

Less than one third of publicly funded trials managed to recruit according to their original plan often resulting in request for additional funding and/or time extensions. As part of the United Kingdom's major public trial funder we sought to identify models which might be useful when estimating likely time requirements for recruiting trial participants. We undertook a systematic review of English language articles using MEDLINE and EMBASE. Only studies discussing prediction of recruitment to trials using a modelling approach were included. Out of 326 identified abstracts, only 8 met all the inclusion criteria. Of these 8 studies examined, there are five major classes of model discussed: the unconditional model, the conditional model, the Poisson model, Bayesian models and Monte Carlo simulation of Markov models. None of these meet all the pre-identified needs of the investigators.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program

2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.