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Abstract Details

Activity Number: 624
Type: Contributed
Date/Time: Thursday, August 2, 2012 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistics in Epidemiology
Abstract - #304342
Title: Estimation of the Common Risk Difference in Stratified Paired Binary Data with Homogeneous Stratum Effect
Author(s): Yan Zhao*+ and Dewi Gabriela Rahardja
Companies: Oklahoma University Health Sciences Center and FDA
Address: 4502 East 41st Street, Tulsa, OK, 74135, United States
Keywords: Cochran-Manten-Hanszel test ; common risk difference ; McNemar's test ; paired binary data ; stratified data

The McNemar's test is commonly used to test for the risk difference between two binary variables on matched pairs. For stratified paired binary data, recently a test for testing homogeneous stratum effect (HSE) has been developed. If HSE is rejected, then the McNemar's test should be applied by stratum; otherwise, in this paper we propose a concept of common risk difference (CRD) across the strata and derive point estimators and confidence intervals for CRD. We use a cancer study for illustration and conduct simulations to recommend point estimators and associated confidence intervals with good statistical property.

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