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Abstract Details
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Activity Number:
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200
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Type:
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Roundtables
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Date/Time:
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Monday, July 30, 2012 : 12:30 PM to 1:50 PM
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Sponsor:
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Health Policy Statistics Section
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| Abstract - #304336 |
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Title:
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Issues in Adaptive Bayesian Dose-Finding Designs
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Author(s):
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Thomas M Braun*+
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Companies:
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University of Michigan
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Address:
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1415 Washington Heights, Ann Arbor, MI, , USA
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Keywords:
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Phase I trial ;
Calibration of Priors ;
Drug Combinations ;
Dose-scheduling finding ;
continual reassessment method
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Abstract:
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We will discuss the use of Bayesian methods in the design of early-phase clinical trials that are designed to find a dose that is safe and/or effective in the treatment of cancer. We will discuss the need for informative prior distributions and how calibration of the prior is necessary for a successful design. We will also cover the multitude of variations that now exist for Phase I designs, including designs for two-agent combinations, dose-schedule finding, incorporating multiple outcomes, and accounting for missing data.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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