JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 29
Type: Contributed
Date/Time: Sunday, July 29, 2012 : 2:00 PM to 3:50 PM
Sponsor: Health Policy Statistics Section
Abstract - #304236
Title: New Stochastic Models of Human Eye Cancer Involving Both Hereditary and Non-Hereditary Cancers
Author(s): Hong Zhou*+ and Wai-Yuan Tan
Companies: Arkansas State University and University of Memphis
Address: 458 Fountain Crest Cv, Memphis, TN, 38120-1868, United States
Keywords: Stochastic equation ; Generalized mixture model ; Retinoblastoma ; Uveal melanoma ; eye cancer

Human eye cancers consist of pediatric eye cancer (retinoblastoma) and adult eye cancer (uveal melanoma). Based on recent biological studies, in this paper we have developed new stochastic models for retinoblastoma and for uveal melanoma respectively. We have further incorporated genetic segregation of cancer genes into these models to derive generalized mixture models for human eye cancers. Based on these models we have developed a generalized Bayesian approach to estimate the parameters and to predict cancer incidence via Gibbs sampling procedures. We have applied these models to fit and analyze the SEER data of human eye cancers from NCI/NIH. Our results indicate that the models not only provide a logical avenue to incorporate biological information but also fits the data much better than other models. These models would not only provide more insights into human eye cancers but also would provide useful guidance for its prevention and control and for prediction of future cancer cases.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program

2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.