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Abstract Details
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Activity Number:
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631
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Type:
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Invited
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Date/Time:
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Thursday, August 2, 2012 : 10:30 AM to 12:20 PM
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Sponsor:
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ENAR
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| Abstract - #303915 |
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Title:
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Studying Histone Modification by CHiP-Seq
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Author(s):
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Nancy R. Zhang*+
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Companies:
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The Wharton School
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Address:
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University of Pennsylvania, Department of Statistics, Philadelphia, PA, 19104,
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Keywords:
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scan statistics ;
false discovery control ;
epigenetics ;
DNA sequencing
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Abstract:
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Chromotin-immunoprecipitation, when paired with next-generation sequencing (ChIP-Seq), is a powerful tool for studying protein-DNA binding at a genome-wide scale. In particular, ChIP-Seq has become the standard method for profiling histone modifications. While there has been many "peak finding" methods for analysis of ChIP-Seq data associated with transcription factor binding, these methods are not well adapted to studying histone modification. I will discuss scan statistics for the detection of differential enrichment of histone modification, and the control of their false discovery rates.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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