JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 1
Type: Invited
Date/Time: Sunday, July 29, 2012 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #303853
Title: Designs for Partially Ordered Phase I Trials
Author(s): Mark Conaway*+ and John O'Quigley and Nolan Wages
Companies: University of Virginia and Universite Paris VI and University of Virginia
Address: Box 800717, Charlottesville, VA, 22908,
Keywords: dose finding ; continual reassessment ; order restricted inference

Most methods for the design of Phase I trials in oncology are intended for studies involving a single cytotoxic agent. The goal of these studies is to estimate the maximally tolerated dose, the highest dose that can be administered with an acceptable level of toxicity. A key assumption of these methods is the monotonicity of the dose-toxicity curve; administration of greater doses of the agent can be expected to produce toxicities in increasing proportions of patients. In this case, the dose-toxicity curve is said to follow a 'simple order' because the ordering of the probabilities of a 'dose-limiting toxicity' (DLT) for any pair of doses is known.

It is becoming increasingly common for combinations of agents to be tested in phase I trials. In these studies, the probabilities of a DLT associated with the dose combinations often follow a 'partial order' in that there are pairs of dose combinations for which the ordering of the probabilities is not known. This talk will review existing methods and outline new methods that combine features of the continual reassessment method and order restricted inference to develop designs for partially ordered phase I trials.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program

2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.