The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Online Program Home
Abstract Details
|
Activity Number:
|
272
|
|
Type:
|
Invited
|
|
Date/Time:
|
Tuesday, July 31, 2012 : 8:30 AM to 10:20 AM
|
|
Sponsor:
|
Section on Statistics in Epidemiology
|
| Abstract - #303590 |
|
Title:
|
Causal Link Between Antiepileptic Drugs and Suicide Attempts: A Propensity Score Matching Analysis in Patients with Bipolar Disorder
|
|
Author(s):
|
Bo Lu*+
|
|
Companies:
|
The Ohio State University
|
|
Address:
|
244 Cunz Hall, Columbus, OH, 43235,
|
|
Keywords:
|
Propensity Score ;
Matching ;
Difference-in-difference ;
AED
|
|
Abstract:
|
In 2008, the Food and Drug Administration (FDA) issued an alert regarding increased risk of suicidal thoughts and behavior related to use of antiepileptic drugs (AEDs). The FDA scientific advisory committee concluded a significant positive association between AEDs and suicidality, but voted against placing a black box warning on AEDs for suicidality. To investigate the causal relationship between use of AEDs and risk of suicide attempts, we implement a propensity score matching analysis for a cohort of patients with bipolar disorder. To accommodate a person-year suicide attempt rate outcome, we modify the potential outcome framework, compare different estimation strategies and elaborate their causal interpretations. The important information on pre-treatment suicide attempts is incorporated in several ways, including matching, regression modeling and a difference-in-difference type of adjustment.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2012 program
|
2012 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.