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Abstract Details

Activity Number: 439
Type: Invited
Date/Time: Wednesday, August 1, 2012 : 8:30 AM to 10:20 AM
Sponsor: Section on Nonparametric Statistics
Abstract - #303563
Title: Fisher-Rao Curve Registration in Proteomics
Author(s): J. Steve Marron*+
Companies: The University of North Carolina at Chapel Hill
Address: Department of Statistics and Operations Research, Chapel Hill, NC, ,
Keywords: curve registration ; time warping ; Fisher Rao
Abstract:

A common challenge for the statistical analysis of various spectra, such as those common to proteomics, is time registration of curves. An approach to data driven time warping for registration, based on the Fisher Rao metric on square root velocity functions, is seen to give a particularly attractive approach, with some important invariance properties. This forms the basis of an intuitve decomposition of the variation into horizontal and vertical components. Especially impressive results are shown for aligning peaks in a Total Ion Chromatography data set.


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